Inverse Dynamical Problems: An Algebraic Formulation Via MP Grammars

Metabolic P grammars are a particular class of multiset rewriting grammars introduced in the MP systems’ theory for modelling metabolic processes. In this paper, a new algebraic formulation of inverse dynamical problems, based on MP grammars and Kronecker product, is given, for further motivating the correctness of the LGSS (Log-gain Stoichiometric Stepwise) algorithm, introduced in 2010s for solving dynamical inverse problems in the MP framework. At the end of the paper, a section is included that introduces the problem of multicollinearity, which could arise during the execution of LGSS, and that defines an algorithm, based on a hierarchical clustering technique, that solves it in a suitable way.